Microstructure and Properties of Natural and Synthetic Biomaterials, Biocomposites, and Interfaces

Successful tissue engineering strategies will require careful characterization of the native tissue and the materials that will replace them as well as interactions between these materials. The complex microstructures in tissues like bone, tendon, and skin, as examples, can present significant experimental and computational challenges. This symposium focuses on the characterization and modeling of natural tissue, synthetic replacement materials, and composites of these materials. Studies on interfacial and heterogeneous tissues (such as osteochondral tidemark regions, tendon and ligament insertion points into bone, scaffold/tissue interfaces ) as well as the development of biomaterials appropriate as analogs of the extracellular matrix for tissue engineering applications are welcome. Work describing experimental or modeling approaches and, in particular, interdisciplinary studies at the intersection of engineering, science and medicine, are also welcome. Potential topics may include microstructural and propertiy characterization of tissues and biomaterials for tissue engineering applications, studies of growth and remodeling, optimization, multi-scale modeling, novel characterization methods, and other.

Organizers


Schedule

Tuesday 3

Room Time Talk
Chancellor Ballroom 2:00 PM Mechanical Behavior of Cells on Tissue Engineering Scaffolds
Lorna Gibson
Chancellor Ballroom 2:40 PM Constitutive and Fracture Behavior of a Soft Biogel, Agarose
Hj Kwon, C. Kovalchick, G. Ravichandran
Chancellor Ballroom 3:00 PM Structure-Property Relationship of Single Electrospun Nanofibers
Chwee Teck Lim
Chancellor Ballroom 3:20 PM Modeling agarose-nanocomposite biomaterials for tissue engineering applications
Kumar Vemaganti, Nilesh Billade, Shawn Hunter

Tuesday 4

Room Time Talk
Chancellor Ballroom 4:00 PM Saw-tooth behavior of bio-macromolecules
Ying Wang, Youping Chen
Chancellor Ballroom 4:20 PM Correlation between Atomic Force Microscope based Experiments and Atomistic Simulations based Deformation Analyses of Bone Tissue
Vikas Tomar, Ming Gan, Albert Cerrone, Devendra K. Dubey
Chancellor Ballroom 4:40 PM Geometric Confinement Governs the Rupture Strength of H-bond Assemblies at a Critical Length Scale
Markus J. Buehler, Sinan Keten
Chancellor Ballroom 5:00 PM Utilization of Atomic Force Microscopy to Study Ligand-Receptor Binding of Immune System Molecules
Irene Chang, Jianzhu Chen, Subra Suresh
Chancellor Ballroom 5:20 PM Hierarchical Chemo-mechanics of Tropocollagen-Hydroxyapatite Nanocomposites: Role of Interfaces and Hierarchy
Vikas Tomar, Devendra K. Dubey

Wednesday 1

Room Time Talk
Chancellor Ballroom 8:00 AM Theory of Swimming Filaments in Viscoelastic Media
Henry Fu, Thomas Powers, Charles Wolgemuth
Chancellor Ballroom 8:20 AM Organ-Level Biomechanical Analysis of Blunt Liver Injury: Dynamic Impact Experiments on Perfused Ex Vivo Porcine Livers
Jessica Sparks, Jason Stammen, Rodney Herriott, John Bolte, Iv
Chancellor Ballroom 8:40 AM Two different Pathways of Abscission Stage of Cytokinesis in Bovine Pulmonary Arterial Endothelial Cells
Tawhid Ezaz, Huseyin Sehitoglu
Chancellor Ballroom 9:00 AM Biorheology of Healthy and Diseased Human Red Blood Cells
David Quinn, Sophie Wong, Subra Suresh

Wednesday 2

Room Time Talk
Chancellor Ballroom 11:00 AM Cartilage tissue engineering on fibrous chitosan scaffolds produced by a replica molding technique
Guillaume R Ragetly, Dominique Griffon, Brian Cunningham, Gregory Slavic
Chancellor Ballroom 11:20 AM Mechanical Property and Biocompatibility of Poly(diol citrate) Micro- and Nanocomposites for Bone Tissue Engineering
Hongjin Qiu, Pradeep Kodali, Jason Koh, Guillermo A, Ameer
Chancellor Ballroom 11:40 AM Hydroxyapatite Scaffolds with Multi-Scale Porosity
Amy Wagoner Johnson, Samantha Polak, Sheeny Lan, Shanna Wilson, Matthew B. Wheeler, Sherrie Clark
Chancellor Ballroom 12:00 PM Scaffold and Growth Factors Induced Regeneration in Critical Size Limb Bone Segmental Defects
Iwona Jasiuk, Liang Feng, Holly Nye, Derek Milner, Chunguang Xia, Patrick Redwood, Jo Ann Cameron, Nick Fang
Chancellor Ballroom 12:20 PM Bioengineered Gelatin Microspheres for Growth Factor Delivery: Improving Xenopus laevis Hind Limb Regeneration
Holly Nye, Derek Milner, Bingbing Li, Nandini Rao, Paul Miller, Kenneth Ringwald, Patrick Redwood, Jo Ann Cameron

Wednesday 3

Room Time Talk
Chancellor Ballroom 2:00 PM Mathematical modeling of cortical bone adaptation in rat ulna
Iwona Jasiuk, Natarajan Chennimalai Kumar, Jonathan A Dantzig, Charles H Turner
Chancellor Ballroom 2:20 PM Assessment of Plasticity in Bovine Cortical Bone During Crack Growth
Denis Torres, Thomas Siegmund, Tamim Diab, David Burr
Chancellor Ballroom 2:40 PM Physical Imaging for Human Cortical Bone Crack Growth
Elisa Budyn, Thierry Hoc, Julien Jonvaux
Chancellor Ballroom 3:00 PM Damage and Energy Dissipation in Trabecular Bone
Glen L. Niebur, Rachel C. Paietta, Jacqueline G. Garrison
Chancellor Ballroom 3:20 PM Transmenopausal Changes in the Intrinsic Material Properties of Trabecular Bone using Nanoindentation
Benjamin J. Polly, Mohammed P. Akhter, Joseph A. Turner

Wednesday 4

Room Time Talk
Chancellor Ballroom 4:00 PM Microstructure and Mechanical Properties of Mineralized Collagen-GAG Scaffolds for Bone Regeneration
Lorna Gibson, Biraja Kanungo, Lorna Gibson, Lorna Gibson
Chancellor Ballroom 4:20 PM Mechanics and surgical strategies for tendon-to-bone repair
Guy M. Genin, Youngjune Yoon, Alistair J. Kent, Brigitte Wopenka, Jill D. Pasteris, Victor Birman, Rosalina Das, Stavros Thomopoulos
Chancellor Ballroom 4:40 PM Nanomechanical property dependence on crystallinity in modern and fossilized bone tissues
Sara Olesiak, Matthew Sponheimer, Jaelyn J. Eberle, Michelle L. Oyen, Virginia L. Ferguson
Chancellor Ballroom 5:00 PM The effects of diets containing 15 and 30% of energy from protein on mechanical strength of the femur in rats
Matthew Thorpe, Rudy Valentine, Amy Wagoner Johnson, Ellen Evans, Donald Layman
Chancellor Ballroom 5:20 PM Dependence of the mechanical properties of sintered hydroxyapatite on the sintering temperature.
Igor Sevostianov, Oleg Prokopiev