Multiscale Modeling in Biological Problems

Biological complexity can only be understood quantitatively by using mathematical sciences. Many fundamentally important processes in biology are inherently multiscale. Multiscale modeling is an approach to understanding the biological processes by integrating analytical and computational models from the molecular to the continuum level across widely different spatial and temporal scales. In the last decade considerable progress has been achieved in the multiscale modeling of complex biological processes, and the success of such models relies upon new theories and methods for constructing accurate multiscale approaches that transfer information between models with different resolutions. Such approaches can be deterministic, stochastic, qualitative, or in many other forms.

The minisymposium is dedicated to the fundamental aspects of multiscale modeling in biological processes. We will explore the latest approaches to developing reliable mathematical models and efficient numerical algorithms to bridge the multiple scales and biological representations. Some of the issues that will be discussed include, but are not limited to: (1) innovative mesoscopic models, which bridge the scales between microscopic and marcoscopic models in biological problems; (2) network approximations and applications to biology; (3) numerical methods that can accurately capture the effects of the small scales on the large ones; (4) multiscale analysis in inverse problems of mathematical biology.

Organizers


Schedule

Monday 4

Room Time Talk
Knowledge Room 4:00 PM Understanding in vivo and in vitro cell matrix interactions through multi-scale modeling and simulations.
Muhammad Zaman
Knowledge Room 4:20 PM A Multiscale Approach to Modeling the Human Respiratory and Circulatory Systems
Anne Staples, Elaine Oran, Jay Boris, Carolyn Kaplan
Knowledge Room 4:40 PM Dependence of the Vibrational Frequency Spectrum of a Nonlinear Residually Stressed Elastic Body on Material Properties, Geometry and Residual Stress
Yuliya Gorb, Jay R. Walton
Knowledge Room 5:00 PM Experimental and Theoretical Studies of Ultimate Strength of Cortical Bone
Iwona Jasiuk, Liang Feng
Knowledge Room 5:20 PM A model of hydrodynamic interaction between self-propelled bacteria
Vitaliy Gyrya , Igor S. Aranson, Leonid V. Berlyand, Dmitry Karpeev

Tuesday 1

Room Time Talk
Knowledge Room 8:00 AM Flocculating Infectious Bacteria: Smoluchowski and Sepsis
David Bortz, John Younger
Knowledge Room 8:20 AM Canceled - Fluid-Structure Interaction and Transport in Blood Flow
Suncica Canic
Knowledge Room 8:40 AM Mechanics of Microtubules Buckling Supported by Cytoplasm
Hanqing Jiang, Jiaping Zhang
Knowledge Room 9:00 AM Modeling of Bone at Nanostructural Level
Iwona M. Jasiuk, Elham Hamed
Knowledge Room 9:20 AM Effective Viscosity of Dilute Bacterial Suspensions: A Two-Dimensional Model
Leonid Berlyand, B. Haines, I. Aronson, D. Karpeeev

Tuesday 2

Room Time Talk
Knowledge Room 11:00 AM Modeling the Growth of an Atherosclerotic Lesion
Jay Walton
Knowledge Room 11:20 AM Multi-scale modeling of alpha-helical protein structures
Markus Buehler
Knowledge Room 11:40 AM Thermodynamically-Consistent Hierarchical Multiscale Constitutive Modeling of Glassy Polymer Materials
Gregory Odegard, Pavan Valavala, Elias Aifantis
Knowledge Room 12:00 PM A Concurrent Atomistic and Continuum Model and Its Application in Biological Materials
Youping Chen, Liming Xiong