Mechanobiology of Cell-Extracellular Matrix Interactions
This symposium focuses on characterization and modeling of interactions between cells and their local extracellular environment, and how these interactions may mediate cell behavior. Work describing modeling and characterization of subcellular mechanisms as well as the behavior of individual or populations of cells, in particular interdisciplinary studies at the intersection of engineering, science and medicine, are welcome. Sample topics include:
- Adhesive interactions between cells and the extracellular matrix
- Stem cell niche mechanobiology
- Integrin-ligand interactions
- Extracellular influences on cell motility, proliferation, and contraction
- Computational modeling of cell behavior and cell-matrix interactions
Organizers
-
Amy Wagoner Johnson
Department of Mechanical Science and Engineering, UIUC
ajwj@uiuc.edu -
Brendan Harley
Department of Chemical and Biomolecular Engineering, UIUC
bharley@mit.alum.edu -
Ning Wang
Department of Mechanical Science and Engineering, UIUC
nwangrw@uiuc.edu -
Taher Saif
Department of Mechanical Science and Engineering, UIUC
saif@uiuc.edu
Schedule
Monday 1
| Room | Time | Talk |
|---|---|---|
| Chancellor Ballroom | 8:00 AM |
Probing cellular responses to substrate rigidity and geometry Yu-Li Wang |
| Chancellor Ballroom | 8:40 AM |
Quantifying the Effects of Preload and Afterload on Cardiomyocytes Using Forcepost Detector Arrays James Norman, Chelsey Simmons, Niveditha Arumugam, Subhanu Samarajiva, Rebecca Taylor, Giovanni Fajardo, Daniel Bernstein, Beth Pruitt |
| Chancellor Ballroom | 9:00 AM |
Quantifying the contractile behavior of individual fibroblasts within 3D collagen scaffolds Brendan Harley, Lorna Gibson |
| Chancellor Ballroom | 9:20 AM |
Matrix Mechanics and Cell Traction Regulate Integrin-Adhesion Ligand Bond Formation by Mesenchymal Stem Cells in 3D Micro-environments Nathaniel Huebsch, Praveen Arany, Angelo Mao, David J. Mooney |
Monday 2
| Room | Time | Talk |
|---|---|---|
| Chancellor Ballroom | 11:00 AM |
Effect of matrix structure and stiffness on sub-cellular visco-elastic properties of tumor cells in 2D and 3D matrices Muhammad Zaman, Erin Baker |
| Chancellor Ballroom | 11:20 AM |
Synthetic Stem Cell Niche for In Vitro Spermatogonial Stem Cell Culture Hyunjoon Kong, Cathy Chu, John Schmidt, Kay Carnes, Zhen Zhang, Marie-Claude Hofmann |
| Chancellor Ballroom | 11:40 AM |
Effects of EGF-induced matrix proteolysis on tumor cell migration in 3D environments arise from increase in cell speed and matrix-dependent increase in directional persistence. Hyung-Do Kim, Tiffany W. Guo, Angela P. Wu, Frank B. Gertler, Douglas A. Lauffenburger |
| Chancellor Ballroom | 12:00 PM |
Bioactive Microgels for Large-Scale Eukaryotic Cell Culture Hyunjoon Kong, John Schmidt |
| Chancellor Ballroom | 12:20 PM |
Mechano-chemical Coupling in the Adhesion of Thin Structures to Surfaces with Topography Richard Springman, John L. Bassani |
Monday 3
| Room | Time | Talk |
|---|---|---|
| Chancellor Ballroom | 2:00 PM |
The Fly Eye: A Biomechanics Model for Understanding Tissue Morphology Sascha Hilgenfeldt, Ian Gemp, Richard Carthew |
| Chancellor Ballroom | 2:20 PM |
Substrate mechanics and chemistry modulate the balance between endothelial cell-cell and cell-matrix adhesion Cynthia Reinhart-King |
| Chancellor Ballroom | 2:40 PM |
Substrate elasticity influences bone-like matrix deposition in low-density mesenchymal stem cell cultures but not in confluent cultures Amy Wagoner Johnson, Michael Poellmann |
| Chancellor Ballroom | 3:00 PM |
Model of Force Generation in a Self-Assembling Toroidal Cluster of Cells Asha Nurse, L. B. Freund |
| Chancellor Ballroom | 3:20 PM |
Composite Diaphragm Inflation: Probing the Mechanobiological Functions of Desmosomes and Intermediate Filament Networks within a Living Normal Human Epidermal Keratinocyte Sheet John Selby, Mark A. Shannon |
Monday 4
| Room | Time | Talk |
|---|---|---|
| Chancellor Ballroom | 4:00 PM |
The thermodynamics and kinetics of focal adhesion dynamics Krishna Garikipati, Joseph E. Olberding, Michael D. Thouless, Ellen M. Arruda |
| Chancellor Ballroom | 4:20 PM |
Measuring the surface adhesion of cancer cells: A novel way to characterize and understand cancer metastasis Xin Tang, Tony Cappa, Theresa B. Kuhlenschmidt, Mark S. Kuhlenschmidt, Taher A. Saif |
| Chancellor Ballroom | 4:40 PM |
Nanomechanics of Cell Adhesion: from single molecules to tissues Deborah Leckband, Yuan-Hung Chien, Ning Jiang, Fang Zhang, Cheng Zhu |
| Chancellor Ballroom | 5:00 PM |
A Second Order Mean Field Theory on the Stochastic-Elasticity Model of Focal Adhesion via Molecular Bond Clusters Huajian Gao, Jizeng Wang, Jin Qian |
Tuesday 1
| Room | Time | Talk |
|---|---|---|
| Chancellor Ballroom | 8:00 AM |
Adhesion site dynamics and cytoskeleton multi-compartmental response revealed by transient bead twisting: Magnetic Twisting Cytometry revisited Daniel Isabey, Féréol Sophie, Pelle Gabriel, Fodil Redouane, Louis Bruno |
| Chancellor Ballroom | 8:20 AM |
Molecular Mechanism of The Multi-Power Law Behavior of Living Cells Farhan Chowdhury, Sungsoo Na, Olivier Collin, Bernard Tay, Fang Li, Tetsuya Tanaka, Deborah Leckband, Ning Wang |
| Chancellor Ballroom | 8:40 AM |
Force Spectroscopy of Primary Alveolar Epithelial Type II Cells Esra Roan, Catherine Cozad, Christopher M. Waters, Lynn Crosby |
| Chancellor Ballroom | 9:00 AM |
Micromechanical Modeling of Cell Cytoskeleton H. Jerry Qi, Sitikantha Roy |
| Chancellor Ballroom | 9:20 AM |
A Coarse Grained Model for Biomembranes George Lykotrafitis, Ju Li, Sulin Zhang, Subra Suresh |
Tuesday 2
| Room | Time | Talk |
|---|---|---|
| Chancellor Ballroom | 11:00 AM |
Forced dissociation of Neural Cell Adhesion Molecules Deborah Leckband, Venkat Maruthamuthu, Klaus Schulten |
| Chancellor Ballroom | 11:20 AM |
Multimodal Perturbation of Intracellular Calcium using Dorsal Cell Adhesion Warren Ruder, James Antaki, Philip Leduc |
| Chancellor Ballroom | 11:40 AM |
TRPV4 channels mediate mechanical control of integrin activation and angiogenesis Charles Thodeti, Donald Ingber |
| Chancellor Ballroom | 12:00 PM |
Integrin-Cadherin Cross-Talk Regulates Cell Motility And Invasiveness Deborah Leckband, Jonathan Silvestre, Pja Kenis |
| Chancellor Ballroom | 12:20 PM |
Stress-Induced Direct Src Activation is Dependent on Microtubule Deformation Sungsoo Na, Olivier Collin, Farhan Chowdhury, Bernard Tay, Mingxing Ouyang, Yingxiao Wang, Ning Wang |
